促进药物经皮吸收的促渗肽研究进展

何俊a,李晓晖b,常明明a,,汪晴a*

中国药学杂志 ›› 2014, Vol. 49 ›› Issue (8) : 627-631.

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中国药学杂志 ›› 2014, Vol. 49 ›› Issue (8) : 627-631. DOI: 10.11669/cpj.2014.08.001
综 述

促进药物经皮吸收的促渗肽研究进展

  • 何俊1a,李晓晖1b,常明明1a,2,汪晴1a*
作者信息 +

Development of Short Peptides for Enhancing Transdermal Drug Delivery

  • HE Jun1a,LI Xiao-hui1b,CHANG Ming-ming1a,2,WANG Qing1a*
Author information +
文章历史 +

摘要

目的总结近10年来一些具有促渗作用的短肽在促进药物经皮吸收方面的应用。方法分析、归纳、总结国内外相关文献,并就促渗肽的种类及特点、促进药物经皮吸收的方式、促渗机制、存在的问题以及发展方向进行了讨论。结果与结论促渗肽能够有效地帮助药物透过角质层到达活性皮肤或者进入体循环。与传统的物理和化学促渗方法相比,这些具有促渗作用的短肽作为一种新的生物促渗剂,具有生物相容性良好、毒性低等优点,同时,促渗肽对胰岛素等生物大分子的经皮促渗作用为研究生物大分子药物新的给药途径带来了希望。

Abstract

OBJECTIVE To summarize the application of some short peptides which have transdermal enhancing activity in recent ten years. METHODS By sorting, analyzing and summarizing domestic and foreign literatures, the types and characteristics of short peptides, the modes of enhancing transdermal drug delivery, enhancing mechanisms, the existing problems and direction of future development were reviewed. RESULTS AND CONCLUSION Penetrating peptides can help drugs penetrate stratum corneum into viable derma or systemic circulation effectively. Compared to conventional physical and chemical methods, short peptides, as novel biological enhancers, have advantages such as good biocompatibility and low toxicity. Meanwhile, short peptides have transdermal enhancing activity for biomacromolecules like insulin, which bring hope for developing novel administration route of biomacromolecule drugs.

关键词

促渗肽 / 透皮给药 / 局部给药 / 生物促渗

Key words

penetrating peptide / transdermal drug delivery / topical drug delivery / biological enhancer

引用本文

导出引用
何俊a,李晓晖b,常明明a,,汪晴a*. 促进药物经皮吸收的促渗肽研究进展[J]. 中国药学杂志, 2014, 49(8): 627-631 https://doi.org/10.11669/cpj.2014.08.001
HE Juna,LI Xiao-huib,CHANG Ming-minga,,WANG Qinga*. Development of Short Peptides for Enhancing Transdermal Drug Delivery[J]. Chinese Pharmaceutical Journal, 2014, 49(8): 627-631 https://doi.org/10.11669/cpj.2014.08.001
中图分类号: R944   

参考文献

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